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Virtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology

Figure 9

The effects of ingestion of hypotonic and hypertonic solutions on urine flow.

These simulations reproduced the conditions shown in Figures 3 and 4 of Uttamsingh et al. [74], which include experimental from Baldes and Smirk [93] and Dean and McCance [75]. A: Urine flow following ingestion of 1 L of water. B: Urine flow following ingestion of hypertonic saline (normalized wrt. the urine flow rate prior to ingestion).

Figure 9

doi: https://doi.org/10.1371/journal.pcbi.1002571.g009