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Short Term Synaptic Depression Imposes a Frequency Dependent Filter on Synaptic Information Transfer
Figure 4
Low frequency signal transfer in a variety of parameter regimes.
Low frequency cross-spectrum (
), auto-spectrum (
), and coherence (
) between a Poisson presynaptic spike train, 
, and postsynaptic conductance, 
, plotted as a function of the presynaptic rate, 
(Ai–iii), the vesicle recovery timescale, 
(Bi–iii), the number of synaptic contacts, 
(Ci–iii), and presynaptic population size, 
(Di–iii). Columns A–C are for a single presynaptic spike train (
). The zero-frequency coherence in Diii is shown for three values of the presynaptic correlation coefficient: 
, 
, and 
. The power spectrum and coherence predicted by the stochastic model (solid blue) and the deterministic model (dashed red) disagree by orders of magnitude unless 
is small, 
is large, 
is small, or 
is large with 
.
doi: https://doi.org/10.1371/journal.pcbi.1002557.g004