Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase
Figure 9
Cavities in DHDPS active sites.
(A) Wild-type E. coli DHDPS; (B) L197Y E. coli engineered dimer; (C) Wild-type MRSA DHDPS. Active site cavities are represented as mesh surfaces (yellow) for the last 100 ns of dim-A, tet-1 and mrsa-1.