Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells
Figure 8
Example regulatory networks supporting the priming mechanisms.
(A) The AI mechanism is consistent with observed intra- and inter-cellular molecular mechanisms for LPS priming, based on counterbalanced IL-10 and IL-12 signaling [19]. (B) The PS mechanism inspires this predicted intracellular molecular mechanism based on the selective activation of C/EBPδ by LD LPS. (C) IFN-γ self-priming and cross-priming to LPS follows the AI and PS mechanisms. Network details are retrieved from the database IPA (@Ingenuity) as well as the experimental literature listed in Table S3. Dashed lines refer to indirect regulations involving autocrine signaling loops.