Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells
Figure 7
Schematic illustration of constructive (PS) and destructive (AI, SD) pathway interference leading to priming effect.
PS results from the activation of the LD-responsive pathway (x2) which cooperates with the other HD-responsive pathway (x1) to boost cytokine expression in response to the following HD stimulus. AI results from activating a LD-responsive pathway (x2), which cancels the inhibition coming from the other HD-responsive inhibitor (x1) during the HD stage. SD results from deactivating a constitutively expressed suppressor (x1) during the priming stage. Red line with arrow head: activation pathway. Blue line with bar head: inhibition pathway. Line width denotes strength of the pathway controlling the downstream cytokine expression.