Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells
Figure 6
Phase diagrams for priming and tolerance in a typical network motif.
(A) Regions of dosing conditions for tolerance and priming are well separated. (B) Both priming and tolerance effects are affected by the duration of two sequential treatments (with the gap period between two doses being fixed). (C) Priming and tolerance are also affected by the duration of the gap between two doses. Very long gaps fail to exhibit either priming or tolerance.