Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells
Figure 5
Analysis of the tolerance data sets.
(A) The unique topologies generating a tolerance effect sorted by topology density. (B) Typical time courses shown with normal (left panel) or elongated (right panel) gap period between the two doses. Solid line: time course tracking the dynamics of the system under the first HD stimulation, in gap period and under a second HD stimulation. Dashed line: time course tracking the dynamics under a single HD treatment; in this case the system is treated with no LPS during the otherwise first HD period. (C) Distribution of the change of x1 level due to the initial HD stimulation reveals two mechanisms to achieve slow relaxation dynamics in the inhibitor (left panel) and the corresponding two backbone motif (right panel).