Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells
Figure 4
Analysis of the robust priming topologies in the SD mechanism.
(A) 139 unique topologies under SD mechanism sorted by topology density (see Figure S6 and Text S1 for detailed discussion). (B) The highest seven density topologies and the backbone motifs. Line widths are proportional to the mean value of samples of the corresponding topology. Dashed lines denote the additional link present in the top topologies but absent in the backbone motif. (C) Combination of the two backbone motifs is common in the SD data sets. 93% of SD data sets are found to contain either Motif I or Motif II as the backbone motif. Among them, 64% contain both Motif I and Motif II.