Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells
Figure 3
Details of the three priming mechanisms.
(A) Backbone motifs (topological features shared by most of the good parameter sets) of each priming mechanism (see Figure S3 and Text S1 for details). The width of a line is proportional to the mean value of the corresponding ωji among data sets under each priming mechanism. The “slow” and “fast” time scales reflect the values of γj in comparison to γ3 = 1. (B–D) Typical time courses and corresponding phase space trajectories with or without LD pretreatment. Bistable results for AI and SD are shown in Figure S5.