Emergence of a Small-World Functional Network in Cultured Neurons
Figure 9
Network-wide burst propagation time as a function of culture age.
Bar chart shows the median burst propagation time (from all transient networks of all cultures at each age), values outside the 5th to 95th percentiles were removed as outliers, giving n = 6–8 for each age). Error bars show 25th and 75th percentiles. A (network-wide) burst was defined as a near-simultaneous (within 250 ms) occurrence of channel bursts on multiple (≥4) channels. A channel was considered to display bursting activity if ≥4 spikes were detected in 100 ms. For each channel included in the burst, recruitment time was the timestamp of the first spike in the ≥4 spikes in 100 ms sequence. Burst propagation time was calculated as the time to recruit all channels in a network-wide burst. At DIVs 28 and 35, this time was significantly lower than at DIV 14.