Emergence of a Small-World Functional Network in Cultured Neurons
Figure 8
Basic topological properties of the transient networks as a function of culture age.
Panels A, B: mean number of links and nodes (respectively) in transient networks, averaged over all cultures at a particular age (solid black lines). Error bars represent ± s.e.m. The mean numbers of links at each culture age suggested an increasing trend in the number of links between DIVs 14 and 28, however the trend was not significant (P = 0.087). Likewise the mean numbers of nodes suggested an increasing trend (P = 0.089). The mean numbers of persistent network links and nodes are shown for reference (dotted red lines). Panels C, D: expected coefficient of variation for the numbers of links and nodes (respectively) in each culture's set of transient networks. Error bars represent ± s.e.m. Coefficient of variation for number of links was significantly higher at DIV 21 than DIV 14 (P = 0.021).