Emergence of a Small-World Functional Network in Cultured Neurons
Figure 7
Visualization of hubs in a representative culture at DIVs 28 and 35.
Graphs illustrate the location of hubs in the persistent network of a representative culture at two separate ages. The 8 by 8 grid corresponds to positions of the electrodes on the multi-electrode array (MEA). Nodes that are part of the network (i.e. for which a link was identified) are numbered according to their MEA hardware numbers, and the lines between electrodes represent un-directed links between nodes. At DIV 28 (left hand graph), nodes 4 and 38 were classified as hubs in the network, whilst at DIV 35 (right hand graph), nodes 34, 38, 40, 48, 49 and 53 were hubs. Hubs were classified as nodes having a high degree (degree greater than mean node degree plus one standard deviation) and are highlighted with blue circles.