Entrainment of the Mammalian Cell Cycle by the Circadian Clock: Modeling Two Coupled Cellular Rhythms
Figure 10
Entrainment of the cell cycle by the circadian clock in the presence of multiple modes of coupling through Wee1, p21, and cyclin E.
Conditions correspond to the black dot in Fig. 9F: the cell cycle period changes from 18 h to 24 h upon coupling (vertical arrow). Shown is the time evolution of cyclin A/Cdk2 (green) and cyclin B/Cdk1 (red) in the absence (t<240 h) or presence (t>240 h) of multiple coupling to the circadian clock. The dashed line represents the LD cycle, as explained in the legend to Figs. 3 and 8. Parameter μ, which measures the coupling strength (see Methods), is equal to 0 for t<240 h and 0.01 for t>240 h.