Entrainment of the Mammalian Cell Cycle by the Circadian Clock: Modeling Two Coupled Cellular Rhythms
Figure 4
Domains of entrainment of the cell cycle by the circadian clock via circadian control of the kinase Wee1.
The domains are determined as a function of the autonomous period of the cell cycle prior to coupling and of the strength of coupling (see text and Methods). We consider that the cell cycle is entrained when Cdk2 and Cdk1 both exhibit one large-amplitude peak per 24 h or 48 h. Entrainment of the cell cycle to 24 h occurs for autonomous periods smaller or larger than 24 h. The domains of entrainment are determined in the presence (A) or absence (B) of a basal rate of synthesis, vswee1, of the kinase Wee1, which is equal to 0.06 µM h−1 or 0, respectively. The size of the domains of entrainment of the cell cycle by the circadian clock increases as the basal rate of synthesis of Wee1 diminishes. Points A–I refer to situations illustrated in Figs. 5–7. The results are obtained as described in the legend to Fig. 2, for vcb = 0.05 µM h−1. Other parameters values are the same as in Fig. 2.