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Are Long-Range Structural Correlations Behind the Aggregration Phenomena of Polyglutamine Diseases?

Figure 1

(a) Schematic of amino acid backbone dihedrals

and , and (b) a corresponding Ramachandran plot. In a typical Ramachandran plot of a glutamine residue, each pixel represents a bin, whose intensity represents its relative population, ranging from 1,2,,9, and 10 or more conformations, sampled in our simulations. Blue, yellow, grey, and pink clusters identify PPII, , , and regions, respectively.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1002501.g001