Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT2A Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties
Figure 4
Dynamics of activation elements in LSD- and KET-bound 5-HT2AR.
(A–E) Left and right panels show the evolution of active state components in the 5-HT2AR complexed with LSD and KET, respectively (for details see Figure 3). (F) Cartoon representation of TM3 and TM6 in the structures averaged over the last 100 ns of the LSD (cyan) and KET (green) trajectories, showing positions of R3.50 and E6.30 residues (in sticks).