Deconvolution of the Cellular Force-Generating Subsystems that Govern Cytokinesis Furrow Ingression
Figure 2
Simulations of interphase cells under various stresses.
A. Simulation of a non-adherent cell, initialized as an ellipsoid, experiencing only passive forces. As expected, the cell rounds up relatively quickly. B. Stresses due to adhesion and protrusion were incorporated into the model to simulate traction-mediated cytofission (Video S1). The stress color scale applies for both panels A and B. Negative stress is inward-directed. C. Furrow ingression dynamics of the cell for the simulation in panel B. The point in time when the furrow diameter and length are equal is defined as the cross-over time (tX) and this distance is known as the cross-over distance. The relative furrow diameter is the ratio of furrow diameter divided by the cross-over distance.