Genome-Scale Modeling of Light-Driven Reductant Partitioning and Carbon Fluxes in Diazotrophic Unicellular Cyanobacterium Cyanothece sp. ATCC 51142
Figure 6
Effects of in silico reaction deletions on flux spans under light-limited conditions.
(A) Effects of deletions are compared to the cases where no reactions were deleted (red bar), or TPD were used as constraints (green bar). The values represent the average flux span across all reactions in central metabolism. Only deletions which lower the flux span by at least >1 mmol·g−1 AFDW·h−1 are presented. (B) Changes in flux spans for specific reactions catalyzed by ribulose bisphosphate carboxylase (RBC) and phosphoglucose isomerase (PGI) between simulations that (i) use TPD data as a constraint (green bars), (ii) delete single reactions (blue and purple bars), (iii) delete two reactions (yellow bar) or (iv) impose no additional constraints (red bars). Reaction abbreviations match those listed in Table S1.