Parameters in Dynamic Models of Complex Traits are Containers of Missing Heritability
Figure 1
Flowchart of computational pipeline.
A heart cell model, a genetic map and a virtual population are tied together by selecting heart model parameters assumed to be under influence of genetic variation and associating the parameter variation to a population of virtual genomes based upon HapMap 3 data. Individual genotypes are mapped into heart model parameters (steps 1–3) and by running the heart cell model parameters are mapped into cell-level phenotypes (step 4). Finally, GWAS analysis is then performed on the virtual population (step 5).