Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines
Figure 6
Modeling the spatio-temporal replication program.
Replication timing (A) and fork orientation
(B) of the configuration
where
corresponds to the origin
positioned at location
and firing at time
. Fork coming from
meets the fork coming from
at the space-time point
defined in Equation (11). The replication timing and fork orientation at the spatial position
are given by Equation (12) from which we deduce the relationship
and in turn Equation (14) for the replication fork polarity and the derivative of the MRT. In this picture of the spatio-temporal replication program, the replication fork velocity
is assumed to be constant and replication is bidirectional from each origin.