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Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines

Figure 2

Replication timing U-domains in different human cell lines.

(A) Average MRT profiles ( SEM) inside detected replication U-domains (Table 2). (B) Corresponding average profiles ( SEM). In (A) and (B), each cell line is identified by a color: BG02 (green), K562 (red), GM06990 (blue), BJ R2 (magenta), and HeLa R2 (cyan). (C) The 2534 BG02 U-domains were centered and ordered vertically from the smallest (top) to the longest (bottom). The MRT profile of each domain is figured along a horizontal line using the MRT (BG02) color map. (D) Same as in (C) but for using the (BG02) color map.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1002443.g002