Comprehensive Modelling of the Neurospora Circadian Clock and Its Temperature Compensation
Figure 9
Simulated results showing the clock period and frq RNA and FRQ protein levels between 20 and 30°C.
In (A) Only frq translation rate changes with temperature. In (B) translation of frq and the translocation of FRQ into the nucleus are temperature-dependent. (C) The translation of frq and the translocation of FRQ into the nucleus are temperature-dependent and frq translation has different activation energies above and below 25°C. Simulated period = closed green circles, experimentally derived period = open green circles. Peak levels of FRQ (closed red circles) and peak and trough levels of frq mRNA (closed black circles).