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Effect of Network Architecture on Synchronization and Entrainment Properties of the Circadian Oscillations in the Suprachiasmatic Nucleus

Figure 3

Individual cell variability.

(A) Concentration of and in different cells. The cell is isolated and entrained by light until , then the number of oscillations (pseudo-cycles) is measured until the relative amplitude is lower than 0.1. (B) Distribution of oscillating and damped cells depending on the parameter variability . ‘Not Osc.’ stands for ‘Not Oscillating’ (see Models). (C) Mean and standard deviation of the pseudo-period of individual cells for different values of . (D) Distribution of the cell dynamics for : more than one third of the cells show sustained oscillations and the others display from 5 to 20 pseudo-cycles. (E) Distribution of the pseudo-periods for for the oscillating and damped cells (see Models).

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1002419.g003