Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies
Figure 6
Structural and functional diversity of the 276 superfamilies.
A & B. Distribution of the number of structurally similar groups and unique multi-domain architectures in these superfamilies. C. Distribution of sequence conservation in the alignments for structurally similar groups (SSG) and D. multi-domain architectures (MDA), as measured by ScoreCons. Although some MDAs are quite diverse, others appear quite conserved, which may be due to some MDAs having relatively few sequences associated with them. E. The distribution of the number of fully described (to the fourth level) E.C. numbers across all 276 superfamilies. F. Shows the largest percentage of sequences with the same E.C. number compared to size of the superfamily observed by the number of sequences with a fully classified E.C. number in the superfamily. A dashed line shows that 50% of superfamilies have greater than 65% of their sequences with the same E.C. number.