Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies
Figure 5
Multi-Domain Architectures as Defined by Ntn Type Amide Hydrolasing Domain.
The ArchSchema graph showing MDAs as defined by the Ntn type amide hydrolasing domain. It should be noted that the MDA representing the single domain has cataloged two sequences that have the amidophosphoribosyltransferase function. These sequences represent two truncated sequences (the truncations resulting from a frame-shift), with the full sequence comprising two domains (highlighted by a caution remark in the UniProtKB record). The two truncated sequences inherit the function from the full sequence. Likewise a glutamate synthase function is also ascribed to a sequence in this MDA but comes from a sequence fragment and is likely to be a longer sequence with more domains. Though rare, this highlights the care that needs to be taken when analysing sequence annotations.