Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies
Figure 2
Summary of Phylogenetic, Functional, Metabolite and Domain Architectures for the Phosphatidylinositol-phosphodiesterase Superfamily.
A diagrammatic representation of the FunTree phylogenetic tree with associated functional data and multi-domain architectures from ArchSchema. Each domain is given a unique colour, with the domain of focus coloured green. Three major clades (C1–C3) are highlighted. Within the first group a number of functional sub-groups can be observed, with differences in function defined by changes in substrate or product formed. The presence of additional domains does not change function.