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Modeling Cortisol Dynamics in the Neuro-endocrine Axis Distinguishes Normal, Depression, and Post-traumatic Stress Disorder (PTSD) in Humans

Figure 4

Simulated free glucocorticoid receptor time series of normal, depressed, and PTSD subjects.

The free glucocorticoid receptor (G) in PTSD is much higher than in normal and depressed subjects indicating a stronger negative feedback loop.

doi: https://doi.org/10.1371/journal.pcbi.1002379.g004