Integrating Flux Balance Analysis into Kinetic Models to Decipher the Dynamic Metabolism of Shewanella oneidensis MR-1
Figure 3
Prediction of growth rates (h−1).
Blue ○: growth rate determined by the Monod model. Red ○: dFBA prediction using the objective function (maximization of growth rate). Green □: dFBA prediction using dual-objective functions (maximization of growth rate and minimization of overall flux). Yellow ◊: the weight of the dual-objective functions that predicted the measured growth rates. Note: the summation of the square of fluxes (∑v2) was a very large number (total 774 fluxes), so the magnitude of weight w was small.