Multi-Scale Modeling of HIV Infection in vitro and APOBEC3G-Based Anti-Retroviral Therapy
Figure 11
Sensitivity analysis in single-cell and multicellular models.
(A) The values of all 17 parameters in the intracellular model have changed by +5% and the percentage change in p for each of them is shown. Two parameters representing the time origins of virus release and particle formation had the highest impact on p. In contrast, parameters such as burst size, the degradation rate of A3G, and the stoichiometry of A3G proteins incorporated in HIV particles had zero or negligible effects on p. For the extracellular model, the effects of parameter variations were studied on two outputs; (B) number of normal cells and (C) number of A3G(−) viruses on the 6th day. In both cases, variations of cells proliferation rate had the highest impact on the extracellular model outputs.