Control of Whole Heart Geometry by Intramyocardial Mechano-Feedback: A Model Study
Figure 7
Simulation of hypertrophic growth of the five myocardial walls.
The fractional change of wall mass per adaptation step is plotted as a function of the number of steps after 20% increase of cardiac output. The numbers 126, 1346 and 1236 refer to the applied combination of sensed variables, used for mechano-feedback (Table 3). After fast mass growth during the first 25 cycles, for combination 126 a slow component remains active for a long time. Convergence with 1236 is best. Convergence with 1346 is also fast, but there is more overshoot.