Control of Whole Heart Geometry by Intramyocardial Mechano-Feedback: A Model Study
Figure 4
Simulation of circulation dynamics and cardiomechanics.
With the CircAdapt model, beat-to-beat circulation dynamics are simulated at moderate exercise (left) and at rest (right). Top: Pressures in left/right ventricle (plv/prv) and aorta/pulmonary artery (pao/ppa), and flows through aortic/pulmonary (qao/qpa) and mitral/tricuspid valves (qmitr/qtric). Lower panels: Stresses in actin and ECM of the 5 cardiac walls and related fiber strains. For exercise and rest, amplitude and time calibrations are the same. Abbreviations LAW, RAW, LVW, SVW, RVW are defined in Fig. 2.