Control of Whole Heart Geometry by Intramyocardial Mechano-Feedback: A Model Study
Figure 3
Modeling control of myocardial wall geometry.
In the CircAdapt model of the whole circulation (left), geometry of the walls determines hemodynamic performance, which in turn determines mechanical load of the wall material (upper right). Local mechano-sensing invokes changes in tissue structure (lower mid) and geometry, by which the control loop for adaptation of wall geometry is closed. A matrix of transfer coefficients (lower right) is used to estimate changes in tissue structure, causing geometry to adapt. Symbols [Sens, M, Geom] are used in Eq. (2–9). Abbreviations are explained in the general list.