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HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection
Figure 8
Epistatic interactions for DNA-dependent polymerization in the presence of TFV-DP.
Solid blue-, green- and red line indicate epistasis with regard to replication 
, resistance 
and fitness 
as defined in eqs. (5)–(7) for the double mutant ‘K65R/M184V’. The black dashed horizontal line indicates the value, where no epistatic interactions occur. The light grey area indicates the in vivo concentrations range of TFV-DP from [56], [71], [73], converted to units 
by assuming a cell volume of 
for unstimulated 
T-cells [72]. All utilized parameters are indicated in Table 1 and Tables S1, S2 (supplementary material).
doi: https://doi.org/10.1371/journal.pcbi.1002359.g008