< Back to Article

HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection

Figure 5

Molecular mechanisms of HIV-1 resistance development against AZT by ATP-mediated excision.

Potential mechanisms for resistance development against AZT through increasing its excision rate via an ATP-mediated mechanism (see eq. (21)). We calculated residual DNA-dependent polymerization of a Poly-T sequence in unstimulated T-cells using eq. (19) with parameters from Tables 1, S1 and S3 (supplementary material). The solid black line shows residual DNA polymerization in the wild type virus, whereas the dotted red line and the dashed blue line refer to residual polymerization if and were decreased- and increased 100-fold respectively.

doi: https://doi.org/10.1371/journal.pcbi.1002359.g005