Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome
Figure 4
Patterns of abundance of functional modules in 649 metagenomic samples covering seven body habitats.
A heatmap of the first five principal components (>95% variance) of module abundances averaged and normalized over each of the seven body sites. Cell color indicates positive (yellow) or negative (blue) variation, with the adjacent Scree plot showing the total variance in each component. The three most positively and negatively covarying modules contributing to each component are shown. Briefly, the first principal component differentiates the skin and gastrointestinal tract, the second differentiates the vaginal habitat, the third the gut, the fourth the supragingival plaque versus other oral sites, and the fifth the nares versus skin.