Kinetic Rate Constant Prediction Supports the Conformational Selection Mechanism of Protein Binding

doi:10.1371/journal.pcbi.1002351

Kinetic Rate Constant Prediction Supports the Conformational Selection Mechanism of Protein Binding

Figure 3

Models a, b, c and d.

The and models, applied to the all the complexes for which kinetic data is available (with outlier 2OZA omitted from models c and d). Complexes in the intersection with the high confidence interactions are shown as circles, with the remainder shown as triangles. Points are coloured according to binding affinity. The combined predictions, applied to the validation set, are also shown. These correspond to the set of high confidence affinities for which the rate constants are not known.

doi: https://doi.org/10.1371/journal.pcbi.1002351.g003