Global Analysis of Small Molecule Binding to Related Protein Targets
Figure 2
(a) Distributions of pairwise sequence identity between orthologs (red) and paralogs (blue).
Distributions in the front represent all pairs retrieved from Ensembl Compara and distributions in the back pairs of targets from our analysis. (b) Distributions of differences in binding affinity between the human target and its rat ortholog (red curve) and distribution of differences in binding affinity between human paralogs (blue curve). For comparison, the distribution of inter-assay differences is outlined (black curve).