A Dynamical Model of Oocyte Maturation Unveils Precisely Orchestrated Meiotic Decisions
Figure 7
Strategy for the adjustment of model parameters.
(A) The constraint that the MAPK module (upper panel) must behave as a bistable switch (example of a bifurcation diagram in middle panel) allows one to determine a parameter domain in a 7-dimensional parameter space (bottom panel). An arbitrary parameter set is chosen within this domain. (B) The constraint that the MPF-APC module (upper panel) must behave as an oscillator under constant stimulation or be excitable upon a transient stimulation, which is associated with a saddle-node bifurcation on an invariant circle (example of a bifurcation diagram in middle panel), allows one to determine a parameter domain in a 15-dimensional parameter space (bottom panel). An arbitrary parameter set is chosen within this domain. (C) The constraint that the whole network (upper panel) must display a maturation behavior associated with a specific time course of its components (MPF time course as an example in middle panel) allows one to determine a parameter domain in the remaining 32-dimensional parameter space (bottom panel). An arbitrary parameter set is chosen within this domain.