Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome
Figure 9
Replication mode of the FHIT locus in fibroblasts and lymphoid cells.
(A) Replication timing profile of the locus in BJ fibroblasts and (B) summary of initiation and termination events mapped in MRC5 fibroblasts (data from Figure 2c and Figure S7 in [58]). The FRA3B region is embedded into a 1.2 Mb CTR that replicates by evenly spread initiations. (C) Replication timing profile of the locus in GM06990 lymphoblasts and (D) summary of initiation and termination events and direction of single forks mapped in JEFF lymphoblastoid cells (data from Figure 2a and Figure S3 in [58]). The FRA3B region maps at the bottom of two converging TTRs where forks move in both directions.