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Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome

Figure 4

Characteristics of CTRs and TTRs.

Blue, green and red curves respectively depict parameters defined at scales 100, 200 and 500 kb. (A, B) Size distribution of CTRs and TTRs (pdf: probability density function). (C, D) Genome coverage of CTRs and TTRs of length>Size (in Mb). (E) Mean TR50 of CTRs. (F) Apparent replication speeds of TTRs (pdf: probability density function). Note that different scales are used on the X-axis for CTRs and TTRs because their sizes are different.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1002322.g004