Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops
Figure 5
Degradation control can increase and decrease the period.
A non-monotonic behaviour can be seen for Per RNA when a gradient of the degradation rate is applied to the system. The graphic represents the period as a function of the degradation rate. We marked 2 points (B, C) in the decreasing period region of the graphic and 2 points (D, E) in the increasing period region. (B, C) The period decreases with increasing degradation rate of Per RNA (dy1). (D, F) The period increases with increasing degradation rate of Per RNA (dy1). The wild type scenario is shown in Figure 3 A.