Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops
Figure 2
In silico expression data fits known experimental data.
The circular graphic shows expression data for 6 variables present in the model: 5 RNAs (Ror-blue; Rev-Erb-red; Bmal-green; Per-violet; Cry-turquoise) and the PER/CRY nuclear pool (orange). Each variable is represented by one ring. The dark colour tone marks the published time interval corresponding to the highest expression level of the given variable. The full yellow circle indicates the peak of expression in our in silico experiments. Correspondent circadian times (CT) in hours are given.