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Role of Histone Tails in Structural Stability of the Nucleosome

Figure 6

NA backbone and groove characteristics.

(A) Probability distributions for DNA backbone dihedral angles. The dihedral angles (O3'-P-O5'-C5'), (P-O5'-C5'-C4'), (O5'-C5'-C4'-C3'), (C5'-C4'-C3'-O3'), (C4'-C3'-O3'-P) and (C3'-O3'-P-O5') obtained from the intact nucleosome simulation are compared with those from the crystal structure (1KX5.pdb). (B) DNA major and minor groove width fluctuations along the sequence (chain I) in the intact nucleosome simulation. Groove widths are calculated as P-P distances using the algorithm of Hassan and Calladine [46] implemented in 3DNA [30].

doi: https://doi.org/10.1371/journal.pcbi.1002279.g006