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Role of Histone Tails in Structural Stability of the Nucleosome

Figure 4

RMSD and order parameter

of histone monomers H3, H4, H2A and H2B. (A) RMSDs for each of the two copies, 1 and 2, of the histone monomer backbone (excluding histone tails) versus simulation time for intact nucleosome. The last frame of the equilibration run was chosen as the reference structure. Trajectory frames were reoriented to the reference structure with least square fitting of backbone atoms (excluding tails). (B) Order parameter of each of the two copies (numbered 1 and 2) of histone monomers H3, H4, H2A and H2B for the four tail-truncated simulations. The reference structures used for RMSD calculations of the truncated and intact nucleosomes were aligned and had zero RMSD. The dotted lines indicate .

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1002279.g004