Virus Replication Strategies and the Critical CTL Numbers Required for the Control of Infection
Figure 1
Schematic representation of budding and lytic virus replication strategies.
On the left, budding viruses: a time after infection of the cell, sufficient epitopes are presented on the cell surface for CTL to recognise and kill the cell; virion production causes an increase in cell mortality,
, at a later time
; and at a later time
, virions begin to be shed from the cell at constant rate
. On the right, lytic viruses: beginning a time
after infection the cell becomes visible to CTL, after time
, stress induced by virus replication within the cell generates an additional mortality rate
; and the infected cell bursts and releases
virions a time
after infection. In both figures,
is the duration of a cell's visibility to CTL before virus release begins. Intervals between events are not shown to any scale.