A Whole-Body Model for Glycogen Regulation Reveals a Critical Role for Substrate Cycling in Maintaining Blood Glucose Homeostasis
Figure 8
Previous experimental results by Hue et al.
Glycogen phosphorylase a (GPa) and glycogen synthase a (GSa) activities in hepatocytes under fed (A) and fasted conditions (B) are redrawn from experimental results by Hue et al. [49]). From left to right, top to bottom in panel A and B: 4 increasing glucose concentrations from 5.5 to 55 mM in the incubation medium caused a sequential inactivation of glycogen phosphorylase and activation of glycogen synthase.