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A Whole-Body Model for Glycogen Regulation Reveals a Critical Role for Substrate Cycling in Maintaining Blood Glucose Homeostasis

Figure 5

Fractional activation of GPa and GSa plotted against blood glucose concentration under two selected

. A: corresponds to a stronger binding between glycogen phosphorylase a (GPa) and GS phosphatase, which results in a strong inhibition on the activation of glycogen synthase (GSa). B: corresponds to a weaker binding between GPa and GS phosphatase, where the inhibition by GPa is partially relieved.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1002272.g005