A Whole-Body Model for Glycogen Regulation Reveals a Critical Role for Substrate Cycling in Maintaining Blood Glucose Homeostasis
Figure 1
Liver glycogen levels control circuit architecture.
Glycogen is synthesized by GSa and broken down into glucose-6-phosphate by GPa. Glycogen levels within the liver are shown in the Fed, Fasting and Fasted state as shaded boxes, with full liver glycogen stores being shown as a solid black box in the Fed portion of the circuit. Arrows indicate which branch of the pathway is active. Substrate cycling occurs in the glycogen-depleted (empty box), Fasted state.