Computational Modeling and Analysis of Insulin Induced Eukaryotic Translation Initiation
Figure 5
Sensitivity analysis of a population of initiation models (N = 40).
Species with a high sensitivity ranking are considered fragile while species with a low sensitivity ranking are considered robust. A. Sensitivity ranking of network species in the presence and absence of insulin. B. Time-course sensitivity ranking of network species. C,D. Sensitivity ranking of network species in the presence and absence of IRS-1 feedback. Black fill denoted complexes containing IRS-1, grey fill denotes PI3K/Akt associated signaling components. Sensitivity values were time averaged over 0–100 minutes and 0–5 minutes, respectively. Error bars denote one standard error in the sensitivity ranking computed over a family of uncorrelated (mean correlation of approximately 0.6) parameter sets selected for the analysis.