Metabolic Regulation in Progression to Autoimmune Diabetes
Figure 6
Markers of insulin resistance in 8–11 week old female NOD mice.
(A) Glucose-stimulated insulin secretion is elevated in the high-risk (HR) group (n = 18) as compared to low-risk (LR) group (n = 12) (measured in NOD Study 3). In the same mice, no significant differences between the HR and LR group were found in (B) glucose tolerance test (GTT) or (C) insulin tolerance test (ITT). (D) Homeostatic model assessment (HOMA-IR) index in LR (n = 13) and HR (n = 25) groups (Study 4), and GLUT4 expression in (E) muscle and (F) white adipose tissue (Study 4). (G) The HR mice at 10 weeks of age have slightly more insulitis. Total 678 islets from 8 LR mice (60–123 islets/each) and 633 islets from 8 HR mice (59–102 islets/each) were graded as in Figure 5A. (H) Plasma leptin (analyzed twice, in Studies 3 and 4, combined data analyzed; n = 24 for LR and n = 43 for HR) and (I) adiponectin (analyzed in Study 4; n = 14 for LR and n = 27 for HR) are elevated in 10-week-old HR mice. * indicates p<0.05.